Abstract

Antibiotic resistance is a major public health concern. Antibiotics are extremely effective in eradicating infectious diseases that until the 1930s had proven to be lethal. However, the occurrence of drug-resistant, disease-causing bacteria has become more acute over the past six decades. The immense need for effective antibiotics can be addressed by developing new therapeutic agents or modifying existing ones. Modifications of vancomycin-class antibiotics have created innovation in therapeutic development but require unsustainable synthetic effort. The strategy presented combines umpolung amide synthesis to avoid epimerization of necessary aryl glycine stereocenters and traditional amide. These conditions are highly desirable and can innovate therapeutic design of glycopeptides and related derivatives.

Speaker Bio 

Rashanique Quarels-Allen is an assistant professor in the Department of Chemistry and Biochemistry at Rowan University. She holds a BS in chemistry from Southern University and A&M College and a PhD in Organic Chemistry from Louisiana State University under the direction of Professor Justin Ragains. She completed her postdoctoral training in the laboratory of Professor Jeffrey Johnston at Vanderbilt University.  Over the past four years, Dr. Quarels has built a research program focused on advancing human health. Specifically, her research efforts are in the areas of developing new peptide therapeutics and new methodologies for building complex scaffolds in organic chemistry. Her current research program is supported by the New Jersey Health foundation and the National Science Foundation. She also serves as Board member-at-large for the National Organization of Black Chemists and Chemical Engineers.

Location:  The November meeting will be held at Dave & Buster's in Blackwood, NJ.  It is conveniently located off both Route 55 and Route 42.  Directions via Google Maps can be accessed by clicking this link.

The event will cost $20 per person for adult members , and $5 per person for active students. A flatbread buffet dinner will be served at the event.

Please RSVP by 11/16 @ 5PM here:https://doodle.com/meeting/participate/id/aOqrPOpd

New Jersey Department of Education Professional Development Provider number = 2538

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Department of Chemistry & Biochemistry, Rowan University, 201 Mullica Hill Rd., Glassboro, NJ 08028 Science Hall, 856-256-4505 This page maintained by Greg Caputo caputo@rowan.edu 856-256-5453
Last modified 9/01/2013